CP-640186 |
| Catalog No.GC13434 |
Le CP-640186 est un inhibiteur de l'acétyl-CoA carboxylase (ACC) actif par voie orale et perméable aux cellules avec des IC50 de 53 nM et 61 nM pour l'ACC1 du foie de rat et l'ACC2 du muscle squelettique du rat respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 591778-68-6
Sample solution is provided at 25 µL, 10mM.
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CP-640186 is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.
References:
[1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111.
[2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.
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