Bruceantin (Synonyms: (–)-Bruceantin, NCI 165563, NSC 165563) |
| Catalog No.GC18048 |
La bruceantine (NSC165563) est d'abord isolée de Brucea antidysenterica, un arbre utilisé en éthiopie pour le traitement du cancer, et une activité a été observée contre le mélanome B16, le cÔlon 38 et la leucémie L1210 et P388 chez la souris.
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Cas No.: 41451-75-6
Sample solution is provided at 25 µL, 10mM.
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Bruceantin(NSC165563) is first isolated from Brucea antidysenterica, a tree used in Ethiopia for the treatment of cancer, and activity was observed against B16 melanoma, colon 38, and L1210 and P388 leukemia in mice.IC50 value:Target: anticancerCell differentiation was induced and c-MYC was down-regulated, suggesting a mechanistic correlation between c-MYC down-regulation and induction of cell differentiation or cell death. Treatment of HL-60 and RPMI 8226 cell lines induced apoptosis, and this involved the caspase and mitochondrial pathways. Moreover, an in vivo study using RPMI 8226 human-SCID xenografts demonstrated that bruceantin induced regression in early as well as advanced tumors, and these significant antitumor responses were facilitated in the absence of overt toxicity.
References:
[1]. Cuendet M, et al. Multiple myeloma regression mediated by bruceantin. Clin Cancer Res. 2004 Feb 1;10(3):1170-9.
[2]. Cuendet M, et al. Antitumor activity of bruceantin: an old drug with new promise. J Nat Prod. 2004 Feb;67(2):269-72.
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