CB-1954 (Synonyms: NSC 115829, Tretazicar) |
| Catalog No.GC43209 |
CB-1954 (CB 1954), un promédicament antitumoral, est hautement sélectif contre la lignée tumorale de rat Walker 256. CB-1954 est activé par voie enzymatique pour générer un agent bifonctionnel, qui peut former des liaisons croisées interbrins ADN-ADN. CB-1954 dans les cellules de rat implique la réduction de son groupe 4-nitro en 4-hydroxylamine par l'enzyme NAD(P)H:quinone oxydoréductase 1 (NQO1).
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Cas No.: 21919-05-1
Sample solution is provided at 25 µL, 10mM.
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CB-1954 is a prodrug that is enzymatically activated to generate an antitumor agent that forms DNA-DNA interstrand crosslinks. In rat Walker 256 carcinoma cells, CB-1954 is reduced by NAD(P)H:quinone oxidoreductase (NQO1) to the cytotoxic derivative 5-(aziridin-1-yl)-4-hydroxylamineo 2 nitrobenzamide, a bifunctional alkylating agent.
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