CCI-006 |
| Catalog No.GC65208 |
CCI-006 est un inhibiteur sélectif et un chimiosensibilisateur des cellules leucémiques réarrangées MLL, en inhibant la respiration mitochondriale entraÎnant une dépolarisation mitochondriale insurmontable et une réponse protéique dépliée pro-apoptotique (UPR) dans un sous-ensemble de cellules leucémiques MLL-r.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 292053-42-0
Sample solution is provided at 25 µL, 10mM.
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CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells[1].
[1]. Somers K, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 Jan 22.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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