CDK4/6-IN-6 (Synonyms: CDK4/6-IN-6) |
| Catalog No.GC64802 |
CDK4/6-IN-6 (exemple A94) est un puissant inhibiteur de CDK4/CDK6 avec un Ki de 0,6 nM et 13,9 nM pour CDK4/Cycline D1 et CDK6/Cycline D3, respectivement.
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Cas No.: 2380321-51-5
Sample solution is provided at 25 µL, 10mM.
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CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].
CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].
[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.
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