Cetrorelix Acetate (SB-075 acetate) (Synonyms: SB-75) |
| Catalog No.GC33467 |
L'acétate de cétrorélix (acétate SB-075) (acétate SB-75) est un puissant antagoniste des récepteurs de l'hormone de libération des gonadotrophines (GnRH) avec une CI50 de 1,21 nM.
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Cas No.: 145672-81-7
Sample solution is provided at 25 µL, 10mM.
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Cetrorelix Acetate is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.
Cetrorelix Acetate inhibits growth of ES-2 cell line at 1000 ng/ml. Cetrorelix Acetate has comparable antiproliferative effects as GnRH-I agonists indicating that the dichotomy of GnRH-I agonists and antagonists might not apply to the GnRH-I system in cancer cells[2].
[1]. Beckers T et al. Characterization of gonadotropin-releasing hormone analogs based on a sensitive cellular luciferase reporter gene assay. Anal Biochem. 1997 Aug 15;251(1):17-23. [2]. Gründker C et al. Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer. Reprod Biol Endocrinol. 2003 Oct 7;1:65.
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