CHR 6494 trifluoroacetate |
| Catalog No.GC50145 |
Le trifluoroacétate CHR 6494 est un puissant inhibiteur de haspin, avec une IC50 de 2 nM. Le trifluoroacétate CHR 6494 inhibe la phosphorylation de l'histone H3T3. Le trifluoroacétate CHR 6494 induit l'apoptose des cellules cancéreuses, dont le mélanome et le cancer du sein. Le trifluoroacétate CHR 6494 peut être utilisé dans la recherche sur le cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1458630-17-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.
Huertas et al (2012) Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 31 1408 PMID:21804608
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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