CID44216842 (Synonyms: Cdc42-IN-1) |
| Catalog No.GC39810 |
CID44216842 (Cdc42-IN-1) est un puissant inhibiteur de plomb de liaison aux nucléotides de guanine sélectif pour Cdc42. Les CE50 pour les mutants Cdc42 WT et Cdc42Q61L sont respectivement de 1, 0 et 1, 2 μM dans le test de liaison GTP. Les CE50 pour les mutants Cdc42 WT et Cdc42Q61L sont respectivement de 0, 3 et 0, 5 μM dans le test de liaison GDP. Utiliser comme sonde moléculaire.
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Cas No.: 1222513-26-9
Sample solution is provided at 25 µL, 10mM.
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CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe[1].
[1]. Lin Hong, et al. Characterization of a Cdc42 Protein Inhibitor and Its Use as a Molecular Probe. J Biol Chem. 2013 Mar 22;288(12):8531-43.
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