CLP 257 |
| Catalog No.GC50127 |
CLP 257 est un activateur KCC2 sélectif du cotransporteur K+-Cl− avec une EC50 de 616 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1181081-71-9
Sample solution is provided at 25 µL, 10mM.
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Selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.
Gagnon et al (2013) Chloride extrusion enhancers as novel therapeutics for neurological diseases. Nat.Med. 19 1524 PMID:24097188
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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