COH34 |
| Catalog No.GC39282 |
Le COH34 est un inhibiteur puissant et spécifique de la poly(ADP-ribose) glycohydrolase (PARG) avec une IC50 de 0,37 nM. COH34 se lie au domaine catalytique de PARG (Kd = 0,547 μM), prolongeant ainsi la PARylation au niveau des lésions de l'ADN et piégeant les facteurs de réparation de l'ADN.
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Cas No.: 906439-72-3
Sample solution is provided at 25 µL, 10mM.
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COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
[1]. Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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