COH34 |
| Catalog No.GC39282 |
COH34는 IC50이 0.37 nM인 강력하고 특이적인 폴리(ADP-리보스) 글리코하이드롤라제(PARG) 억제제입니다. COH34는 PARG의 촉매 도메인(Kd=0.547μM)에 결합하여 DNA 병변에서 PARylation을 연장하고 DNA 복구 인자를 트래핑합니다.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 906439-72-3
Sample solution is provided at 25 µL, 10mM.
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COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
[1]. Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340.
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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