D-I03 |
| Catalog No.GC39149 |
D-I03 est un inhibiteur sélectif de RAD52 avec un Kd de 25,8 μM. D-I03 inhibe spécifiquement le recuit simple brin (SSA) dépendant de RAD52 et la formation de boucles D avec des IC50 de 5 μM et 8 μM, respectivement. D-I03 supprime la croissance des cellules déficientes en BRCA1 et BRCA2 et inhibe la formation de foyers RAD52 induits par des dommages, mais n'a pas d'effet sur les foyers RAD51 induits par le cisplatine.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 688342-78-1
Sample solution is provided at 25 µL, 10mM.
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D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 µM and 8 µM, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin[1][2].
[1]. Huang F, et al. Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors. Nucleic Acids Res. 2016 May 19;44(9):4189-99. [2]. Hengel SR, et al. Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119. [3]. Sullivan-Reed K, et al. Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Rep. 2018 Jun 12;23(11):3127-3136.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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