Deferoxamine |
| Catalog No.GC68955 |
Deferoxamine (Deferoxamine B) is a iron chelator (binding Fe(III) and many other metal cations), widely used to reduce the accumulation and deposition of iron in tissues. Deferoxamine has good antioxidant activity, can upregulate HIF-1α levels. Deferoxamine also has anti-proliferative activity, inducing cancer cell apoptosis and autophagy. Deferoxamine can be used for research on diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 studies.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 70-51-9
Sample solution is provided at 25 µL, 10mM.
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Deferoxamine (Deferoxamine B) is an iron chelator (binding Fe(III) and many other metal cations), widely used to reduce the accumulation and deposition of iron in tissues. Deferoxamine has good antioxidant activity, can upregulate HIF-1α levels. Deferoxamine also has anti-proliferative activity, inducing cancer cell apoptosis and autophagy. Deferoxamine can be used for research on diabetes, neurodegenerative diseases, as well as anti-cancer and anti-COVID-19 studies.
[1]. Duscher D, et al. Comparison of the droxylase Inhibitor Dimetloxalylglycine and the Iron Chelator Deferoxamine in Diabetic and Aged Wound Healing. Plast Reconstr Surg. 2017 Mar;139(3):695e-706e.
[2]. Dongiovanni P, et al. Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am J Pathol. 2008 Mar;172(3):738-47.
[3]. Wang G, et al. In vitro assessment of deferoxamine on mesencmal stromal cells from tumor and bone marrow. Environ Toxicol Pharmacol. 2017 Jan;49:58-64.
[4]. Wu Y, et al. Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1 alpha and induction of autophagy in SH-SY5Y cells. Neurochem Int. 2010 Oct;57(3):198-205.
[5]. Bellotti D, et al. Deferoxamine B: A Natural, Excellent and Versatile Metal Chelator. Molecules. 2021 May 28;26(11):3255.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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