DPTIP |
| Catalog No.GC50602 |
Le DPTIP est un puissant inhibiteur de la sphingomyélinase neutre 2 (N-SMase 2) pénétrant dans le cerveau (inhibiteur de l'exosome), avec une IC50 de 30 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 351353-48-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo. Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.
Rojas et al (2018) DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci.Rep. 8 17715 PMID:30531925
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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