E-7386 |
| Catalog No.GC33403 |
E-7386 est un modulateur CBP/bêta-caténine actif par voie orale.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1799824-08-0
Sample solution is provided at 25 µL, 10mM.
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E-7386 is an orally active CBP/beta-catenin modulator.
E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group[1].
[1]. Yusaku Hori, et al. E7386, an orally active CBP/beta-catenin modulator, induces T cells infiltration into tumor and enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. Cancer Res 2017;77(13 Suppl):Abstract nr 5172.
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