E3 ligase Ligand-Linker Conjugates 8 (Synonyms: VH032-C6-PEG3-C4-Cl; VHL Ligand-Linker Conjugates 12; E3 ligase Ligand-Linker Conjugates 8) |
| Catalog No.GC32987 |
E3 ligase Ligand-Linker Conjugates 8 (VH032-C6-PEG3-C4-Cl) est un conjugué de ligands pour E3 et un linker de 20 atomes de longueur. Le connecteur du lieur est le groupe halogène. Les conjugués ligand-lieur E3 ligase 8 incorporent le ligand VHL À base de (S,R,S)-AHPC et un lieur À base d'alkyle/éther. E3 ligase Ligand-Linker Conjugates 8 est capable d'induire la dégradation de GFP-HaloTag7 dans des tests cellulaires.
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Cas No.: 1835705-55-9
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand-Linker Conjugates 8 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
E3 ligase Ligand-Linker Conjugates 8 uses the cereblon ligand[1]. The linker is 6-2-2-6. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. E3 ligase Ligand-Linker Conjugates 8 can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2].
[1]. US 20170121321 A1 [2]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.
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