ERK-IN-3 benzenesulfonate (Synonyms: ERK-IN-3 benzenesulfonate) |
| Catalog No.GC63459 |
Le benzènesulfonate ERK-IN-3 est un inhibiteur puissant et oralement actif de l'ERK. Le benzènesulfonate ERK-IN-3 inhibe ERK1/2 avec de faibles valeurs IC50 nM À un chiffre. Le benzènesulfonate ERK-IN-3 peut être utilisé pour la recherche sur les cancers provoqués par des mutations RAS.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2055597-39-0
Sample solution is provided at 25 µL, 10mM.
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ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK. ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancers driven by RAS mutations[1].
ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines[1].ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines[1].
ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses[1].
[1]. Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
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