Fmoc-N-methyl-PEG3-CH2CH2COOH |
| Catalog No.GC66813 |
Le Fmoc-N-méthyl-PEG3-CH2CH2COOH est un lieur ADC clivable utilisé dans la synthèse de conjugués anticorps-médicament (ADC). Le Fmoc-N-méthyl-PEG3-CH2CH2COOH est également un lieur PROTAC à base de PEG qui peut être utilisé dans la synthèse des PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1807518-77-9
Sample solution is provided at 25 µL, 10mM.
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Fmoc-N-methyl-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-N-methyl-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Yang Y,et al. Design, synthesis, and biological characterization of novel PEG-linked dimeric modulators for CXCR4. Bioorg Med Chem. 2016 Nov 1;24(21):5393-5399.
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