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Fmoc-N-methyl-PEG3-CH2CH2COOH

カタログ番号GC66813

Fmoc-N-メチル-PEG3-CH2CH2COOH は、抗体薬物複合体 (ADC) の合成に使用される切断可能な ADC リンカーです。 Fmoc-N-methyl-PEG3-CH2CH2COOH は、PROTAC の合成に使用できる PEG ベースの PROTAC リンカーでもあります。

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Fmoc-N-methyl-PEG3-CH2CH2COOH 化学構造

Cas No.: 1807518-77-9

サイズ 価格 在庫数 個数
100mg
$978.00
在庫あり
250mg
$1,672.00
在庫あり
500mg
$2,430.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents

Fmoc-N-methyl-PEG3-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-N-methyl-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Yang Y,et al. Design, synthesis, and biological characterization of novel PEG-linked dimeric modulators for CXCR4. Bioorg Med Chem. 2016 Nov 1;24(21):5393-5399.

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