E3 ligase Ligand-Linker Conjugates 49 (Synonyms: Cereblon Ligand-Linker Conjugates 14; E3 ligase Ligand-Linker Conjugates 49) |
| Catalog No.GC35956 |
Conjugués ligand-linker E3 ligase 49 est un conjugué ligand-linker E3 ligase synthétisé qui incorpore le ligand cereblon À base de pomalidomide et un linker utilisé dans la technologie PROTAC.
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Cas No.: 2351103-63-2
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand-Linker Conjugates 49 incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a PROTAC linker. E3 ligase Ligand-Linker Conjugates 49 can be used to design PROTAC degrader. Cereblon
[1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins withPicomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481.
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