GLPG2451 |
| Catalog No.GC36149 |
Le GLPG2451 est un potentialisateur du régulateur de la conductance transmembranaire de la fibrose kystique (CFTR), qui potentialise efficacement le CFTR F508del sauvé À basse température avec une EC50 de 11,1 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2055015-61-5
Sample solution is provided at 25 µL, 10mM.
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GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1]. Cystic fibrosis transmembrane conductance regulator[1]
GLPG2451 has an EC50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells[1].
[1]. Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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