MBM-17 |
| Catalog No.GC36552 |
MBM-17 est un puissant inhibiteur de la kinase 2 (Nek2) liée À NIMA avec une IC50 de 3 nM. Il inhibe efficacement la prolifération des cellules cancéreuses en induisant l'arrêt du cycle cellulaire et l'apoptose. Le MBM-55 présente des activités antitumorales et aucune toxicité évidente pour les souris.
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Cas No.: 2083621-90-1
Sample solution is provided at 25 µL, 10mM.
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MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1]. IC50: 3 nM (Nek2), 5800 nM (Aurora A)[1]
MBM-17 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.48, 1.06, 4.53 μM, respectively[1].
[1]. Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.
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