MBM-17 |
| Katalog-Nr.GC36552 |
MBM-17 ist ein potenter Inhibitor der NIMA-verwandten Kinase 2 (Nek2) mit einem IC50 von 3 nM. Es hemmt wirksam die Proliferation von Krebszellen, indem es den Zellzyklusarrest und die Apoptose induziert. MBM-55 zeigt AntitumoraktivitÄten und keine offensichtliche ToxizitÄt fÜr MÄuse.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2083621-90-1
Sample solution is provided at 25 µL, 10mM.
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MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1]. IC50: 3 nM (Nek2), 5800 nM (Aurora A)[1]
MBM-17 inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.48, 1.06, 4.53 μM, respectively[1].
[1]. Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.
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