MC-VC-PABC-DNA31 |
Catalog No.GC36577 |
MC-VC-PABC-DNA31 est un conjugué médicament-lieur pour ADC avec une puissante activité antitumorale en utilisant DNA31 (un puissant inhibiteur de l'ARN polymérase), lié via le lieur ADC MC-VC-PABC.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1639352-03-6
Sample solution is provided at 25 µL, 10mM.
MC-VC-PABC-DNA31 has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. MC-VC-PABC-DNA31 is used for the antibody-drug conjugates (ADC) that are effective and stable in vitro and in vivo to treat various diseases or disorders[1].
[1]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.
Average Rating: 5
(Based on Reviews and 3 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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