Nimustine hydrochloride (Synonyms: ACNU, NSC-D 245382) |
| Catalog No.GC36743 |
Le chlorhydrate de nimustine (ACNU) est un agent de réticulation et d'alkylation de l'ADN, qui induit des lésions bloquant la réplication de l'ADN et des cassures double brin de l'ADN et inhibe la synthèse de l'ADN, couramment utilisé en chimiothérapie pour les glioblastomes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 55661-38-6
Sample solution is provided at 25 µL, 10mM.
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Nimustine hydrochloride (ACNU) is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas[1][2][3].
[1]. Tomicic MT, et al. Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. Oncotarget. 2015 Oct 20;6(32):33755-68. [2]. Kondo N, et al. FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. PLoS One. 2011 May 9;6(5):e19659. [3]. Mineura K, et al. DNA lability induced by nimustine and ramustine in rat glioma cells. J Neurol Neurosurg Psychiatry. 1988 Nov;51(11):1391-4.
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