Tubulysin H |
| Catalog No.GC37842 |
La tubulysine H est un peptide hautement cytotoxique isolé des espèces myxobactériennes Archangium geophyra et Angiococcus disciformis. La tubulysine affiche une activité cytotoxique extrêmement puissante dans les cellules de mammifères, y compris les lignées cellulaires multirésistantes, avec des valeurs IC50 dans la gamme nanomolaire inférieure. La tubulysine H est une tubulysine À activité cytotoxique qui inhibe la polymérisation de la tubuline et conduit À l'arrêt du cycle cellulaire et À l'apoptose.
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Cas No.: 799822-09-6
Sample solution is provided at 25 µL, 10mM.
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Tubulysin H is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis[1]. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[2]. Tubulysin H is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[3].
[1]. Steinmetz H, et al. Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria. Angew Chem Int Ed Engl. 2004 Sep 20;43(37):4888-92. [2]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. [3]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.
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