Glyco-Obeticholic Acid (Synonyms: Obeticholic Acid Glycine Conjugate) |
| Catalog No.GC45466 |
L'acide glyco-obéticholique est un métabolite actif de l'acide obéticholique.
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Cas No.: 863239-60-5
Sample solution is provided at 25 µL, 10mM.
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Glyco-obeticholic acid is an active metabolite of obeticholic acid, which is a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid .1 Glyco-obeticholic acid is formed from obeticholic acid by glycine conjugation in the liver but can be reconverted back to obeticholic acid by microorganism-mediated deconjugation in the ileum and colon. It has been used as a precursor in the synthesis of bile acid analogs as agonists of the farnesoid X receptor (FXR) and TGR5.2
References
1. Markham, A., and Keam, S.J. Obeticholic Acid: First global approval. Drugs 76(12), 1221-1226 (2016).
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