N1-Methyladenosine-5'-Triphosphate |
Catalog No.GN20030
One-Click Copy Product Info
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N1-Methyladenosine-5'-Triphosphate est un dérivé de nucléoside triphosphate synthétique.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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N1-Methyladenosine-5'-Triphosphate est un dérivé de nucléoside triphosphate synthétique [1]. N1-Methyladenosine-5’-Triphosphate est une adénosine méthylée en position N1 sur la base de l'adénosine triphosphate (ATP) [2-3]. N1-Methyladenosine-5’-Triphosphate sert à la synthèse de mRNA avec une immunogénicité réduite et une stabilité améliorée[4]
References:
[1]. Andries O, Mc Cafferty S, De Smedt SC, et al. N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice. Journal of Controlled Release. 2015 Nov 10; 217: 337-344.
[2]. Francis L. The Roles of Endonucleolytic Cleavage in RNA Metabolism and Transcriptional Termination. University of Exeter (United Kingdom); 2019.
[3]. Morena F, Argentati C, Bazzucchi M, et al. Above the epitranscriptome: RNA modifications and stem cell identity. Genes. 2018 Jun 28; 9(7): 329.
[4]. Li D, Bian L, Cui L, et al. Heterologous Prime-Boost Immunization Strategies Using Varicella-Zoster Virus gE mRNA Vaccine and Adjuvanted Protein Subunit Vaccine Triggered Superior Cell Immune Response in Middle-Aged Mice. International Journal of Nanomedicine. 2024 Dec 31: 8029-8042.
| purity | >90.00% | Extinction Coefficient | 14,600 Lmol-1cm-1 at 257 nm |
| Formula | C11H18N5O13P3 (free acid) | M.Wt | 521.20 g/mole (free acid) |
| Salt Form | Li+ | Concentration | 100 mM |
| Buffer | H2O | Storage | -20°C or below |
| Synonymes | N1-Methyl-ATP | Backbone | 5'-Triphosphate |
| Base Analog | Adenosine | Sugar Type | RNA |
| Nucleotide Category | Base Modified RNA | ||
| Applications | Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies | ||
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)