GNE-371 |
| Catalog No.GC30529 |
GNE-371 est une sonde chimique puissante et sélective pour les deuxièmes bromodomaines de la sous-unité 1 TFIID du facteur d'initiation de la transcription humaine et de la sous-unité 1 du facteur d'initiation de la transcription TFIID, avec une IC50 de 10 nM pour TAF1(2).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1926986-36-8
Sample solution is provided at 25 µL, 10mM.
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GNE-371 is a potent and selective chemical probe for the second bromodomains of human transcription-initiation-factor TFIID subunit 1 and transcription-initiation-factor TFIID subunit 1-like, with an IC50 of 10 nM for TAF1(2).
GNE-371 (compound 27) binds TAF1(2) with an IC50 of 10 nM while maintaining excellent selectivity over other bromodomain-family members. GNE-371 is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM) and exhibits anti-proliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371 and further supporting the use of GNE-371 in mechanistic and target-validation studies[1].
[1]. Wang S, et al. GNE-371, a Potent and Selective Chemical Probe for the Second Bromodomains of Human Transcription-Initiation-Factor TFIID Subunit 1 and Transcription-Initiation-Factor TFIID Subunit 1-like. J Med Chem. 2018 Oct 25;61(20):9301-9315.
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