GSK 2250665A |
| Catalog No.GC50156 |
GSK 2250665A (composé 13) est un inhibiteur sélectif d'Itk avec un pKi de 9,2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1246030-96-5
Sample solution is provided at 25 µL, 10mM.
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Itk inhibitor (pKi = 9.2). Exhibits selectivity for Itk over Aurora B kinase and Btk (pIC50 values are 6.4 and 6.5, respectively) and a panel of other kinases. Inhibits IFNγ production in PBMCs.
Alder et al (2013) Identification of a novel and selective series of Itk inhibitors via a template-hopping strategy. ACS Med.Chem.Lett. 12 948 PMID:24900590
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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