HCoV-229E-IN-1 |
| Catalog No.GC62414 |
HCoV-229E-IN-1 est un puissant inhibiteur de la réplication de HCoV-229E, avec une CE50 de 0,65 μM et 0,6 μM dans les cellules MTS et CPE, respectivement .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2639757-13-2
Sample solution is provided at 25 µL, 10mM.
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HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, with an EC50 of 0.65 μM and 0.6 μM in MTS and CPE cells, respectively[1].
HCoV-229E-IN-1 (compound 5h) (0.01-100 μM) fully suppresses the capacity of HCoV-229E replication in a dose-dependent manner[1].HCoV-229E-IN-1 (12 μM) fully prevented the formation of dsRNA intermediates of CoV RNA synthesis[1].
[1]. Stevaert A, et, al. Betulonic Acid Derivatives Interfering with Human Coronavirus 229E Replication via the nsp15 Endoribonuclease. J Med Chem. 2021 May 13;64(9):5632-5644.
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