Hexa-D-arginine (Synonyms: Furin Inhibitor II) |
| Catalog No.GC10318 |
L'hexa-D-arginine (Furin Inhibitor II) est un inhibiteur stable de la furine avec des valeurs Ki de 106 nM, 580 nM et 13,2 μM pour la furine, PACE4 et la prohormone convertase-1 (PC1), respectivement.
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Cas No.: 673202-67-0
Sample solution is provided at 25 µL, 10mM.
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Hexa-D-arginine is an inhibitor of furin.
Hexa-D-arginine (10 μM) protects against the cytotoxic effects of anthrax toxin in RAW 264.7 cells. The concentrations of Hexa-D-arginine requires to block the cleavage of PA are similar to those required to inhibit toxicity[2].
Administration of hexa-d-arginine to PEA-treated mice significantly improves their survival rate and also decreases circulating levels of tumor necrosis factor alpha[1]. Rats treated with the combination of anthrax toxins and Hexa-D-arginine exhibit a 40% survival rate at 5 h compared with a control group treated solely with anthrax toxin (0% survival rate). Administration of Hexa-D-arginine (1 mg/100 μL) also results in a considerable delay in the onset of anthrax toxemia compared with results of the control group treated solely with anthrax toxin[2].
References:
[1]. Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.
[2]. Sarac MS, et al. Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun. 2004 Jan;72(1):602-5.
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