Idoxuridine (Synonyms: 5-iodo-2′-deoxyuridine, NSC 39661, SKF 14287) |
Catalog No.GC13247 |
L'idoxuridine (5-Iodo-2′-désoxyuridine, 5-IUdR, IdUrd) est un analogue iodé de la thymidine qui inhibe de manière compétitive les phosphorylases.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 54-42-2
Sample solution is provided at 25 µL, 10mM.
Idoxuridine is an antiviral agent for feline herpesvirus type-1 with IC50 of 4.3 μM.Target: herpesvirus type-1Idoxuridine is mainly used topically to treat herpes simplex keratitis. Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster.
References:
[1]. Seth AK, et al. Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.Pharm Dev Technol. 2004 Aug;9(3):277-89.
[2]. Fauth E, et al. Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting. Mutat Res. 1999 Apr 6;440(2):147-56.
[3]. Otto SE. Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine). J Intraven Nurs. 1998 Nov-Dec;21(6):335-7.
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