J22352 |
| Catalog No.GC34629 |
J22352 est un inhibiteur HDAC6 de type PROTAC (protéolyse-ciblage des chimères) et hautement sélectif avec une valeur IC50 de 4,7 nM. J22352 favorise la dégradation de HDAC6 et induit des effets anticancéreux en inhibant l'autophagie et en déclenchant la réponse immunitaire antitumorale dans les cancers du glioblastome, et en conduisant À la restauration de l'activité antitumorale de l'hÔte en réduisant l'activité immunosuppressive de PD-L1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2252395-44-9
Sample solution is provided at 25 µL, 10mM.
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J22352 is a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM. J22352 promotes HDAC6 degradation and induces anticancer effects by inhibiting autophagy and eliciting the antitumor immune response in glioblastoma cancers, and leading to the restoration of host antitumor activity by reducing the immunosuppressive activity of PD-L1[1]. HDAC6|4.7 nM (IC50)
J22352 (0.1-20 μM; 72 hours) decreases U87MG cell viability in a dose-dependent manner[1]. J22352 (10 μM; 24 hours) shows a dose-dependent decrease in HDAC6 protein abundance[1]. Cell Viability Assay[1] Cell Line: U87MG cells
J22352 (10mg/kg; given i.p. per day for 14 days in male nude mice) results in a >80% tumor growth inhibition (TGI) rate. J22352 is well tolerated in mice[1]. Animal Model: Male nude mice (BALB/cAnN.Cg-Foxnlnu/CrlNarl, 4-6 weeks old)[1]
[1]. Liu JR, et al. High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma. Biochem Pharmacol. 2019 May; 163:458-471.
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