K-Ras-IN-1 |
| Catalog No.GC33153 |
K-Ras-IN-1 est un inhibiteur de K-Ras. K-Ras-IN-1 se lie À K-Ras (WT), K-Ras (G12D), K-Ras (G12V) et H-Ras. K-Ras-IN-1 a un potentiel pour la recherche sur les carcinomes du pancréas, du cÔlon et du poumon.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 84783-01-7
Sample solution is provided at 25 µL, 10mM.
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K-Ras-IN-1 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.(the detailed information refer to the reference)
[1]. Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54(2):530-538. [2]. Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51(25):6140-6143
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