KLD-12 TFA |
Catalog No.GC72138
One-Click Copy Product Info
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KLD-12 TFA est la forme de sel TFA de KLD-12.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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KLD-12 TFA forms self-assembled polypeptide with SDF-1, improves the survival of bone marrow stromal cells (BMSCs), promotes osteogenic differentiation of BMSCs and cell migration through Wnt/β-catenin pathway[1].
KLD-12 TFA (10-250 μg/rat, single dose, injection to infrature site) promotes bone regeneration at the fracture site in a dose-dependent manner in Sprague-Dawley rats model with drill-hole injury in femur[2].
References:
[1]. Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCsviathe Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29(10):851-858.
[2]. Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103.
[3]. Kisiday J, Jet al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001.
| Cas No. | SDF | ||
| Formula | C68H122N16O19.xC2HF3O2 | M.Wt | 1467.79 (free base) |
| Solubility | DMSO : 50 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) | Storage | Sealed storage, away from moisture |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 681.3 μL | 3.4065 mL | 6.813 mL |
| 5 mM | 136.3 μL | 681.3 μL | 1.3626 mL |
| 10 mM | 68.1 μL | 340.6 μL | 681.3 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)