KRAS inhibitor-10 |
| Catalog No.GC62486 |
L'inhibiteur de KRAS-10 inhibe sélectivement et efficacement les protéines RAS, et en particulier les protéines KRAS. L'inhibiteur de KRAS-10 est un agent anticancéreux actif par voie orale et peut être utilisé pour la recherche sur le cancer, comme le cancer du pancréas, le cancer du sein, le myélome multiple, la leucémie et le cancer du poumon. L'inhibiteur de KRAS-10 est un composé de tétrahydroisoquinoline (composé 11) extrait du brevet WO2021005165 A1.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2578876-75-0
Sample solution is provided at 25 µL, 10mM.
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KRAS inhibitor-10 selectively and effectively inhibit RAS proteins, and particularly KRAS proteins. KRAS inhibitor-10 is an orally active anti-cancer agent and can be used for cancer research, such as pancreatic cancer, breast cancer, multiple myeloma, leukemia and lung cancer. KRAS inhibitor-10 is a tetrahydroisoquinoline compound (compound 11) extracted from patent WO2021005165 A1[1].
KRAS inhibitor-10 (0.1-50 µμ; 72 hours) has antiproliferative effects in KRas mutant tumor cells, KRAS inhibitor-10 is against A549 (lung carcinoma cell line bearing KRasG12S oncogenic mutation), H358 (non-small cell lung cancer line bearing KRasG12C oncogenic mutation), PANC-1 (epithelioid carcinoma of the pancreas cell line bearing KRasG12D oncogenic mutation) and RPMI (myeloma cell line bearing KRasG12A oncogenic mutation) cell proliferation with IC50 values of 0.2 μM, 0.2 μM, 0.1 μM and 0.8 μM, respectively[1].KRAS inhibitor-10 (0-1 μM, 7 days) is against cell viability in a 3D CellTiter-GloTM cell viability assay for NIH-H358 cell, the IC50 value is 0.413 μM[1].
KRAS inhibitor-10 (oral administration; 20 mg/kg; BID; 27 days) is safe and tolerate for the bearing mice. KRAS inhibitor-10 demonstrates significant oral anti-tumor activities in vivo. And the tumor growth inhibition (TGI) value is 48.22% for KRAS inhibitor-10[1].
[1]. Miguel VEGA GARCÍA, et al. Tetrahydroisoquinoline compounds. Patent wo2021002165
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