KRpep-2d TFA |
| Catalog No.GC65032 |
KRpep-2d (TFA) est un puissant inhibiteur de K-Ras et inhibe la prolifération des cellules cancéreuses induites par K-Ras. KRpep-2d peut être utilisé pour la recherche sur le cancer.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].
KRpep-2d (TFA) has cyclic structure with importance for K-Ras inhibitory activity. Leu77 , Ile9 , and Asp12 are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d[1]. KRpep-2d (TFA) (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM)[1].
[1]. Niida A, et al. Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761.
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