LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) |
| Catalog No.GC34168 |
Le dichlorhydrate de LCL521 (dichlorhydrate de 1,3DMG-B13) est un inhibiteur de la céramidase acide (ACDase). LCL521 inhibe également la sphingomyélinase acide lysosomale (ASMase).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1226759-47-2
Sample solution is provided at 25 µL, 10mM.
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LCL521 dihydrochloride (1,3DMG-B13 dihydrochloride) is an acid ceramidase (ACDase) inhibitor. LCL521 also inhibits the lysosomal acid sphingomyelinase (ASMase).
LCL521 (1 µM) acts as a potent inhibitor of cellular ACDase activity, whereas 10 µM LCL521 has an additional, decreased affect on the α-form of this enzyme. LCL521 (10µM) causes a time-dependent (1 hours and 5 hours) decrease of the α-ACDase form in MCF7 cells[1].
[1]. Bai A, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.
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