LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) |
| Catalog No.GC39398 |
LSKL, inhibiteur de la thrombospondine (TSP-1) TFA est un tétrapeptide dérivé de la protéine associée À la latence (LAP)-TGFβ et un antagoniste compétitif du TGF-β1. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibe la liaison de TSP-1 au LAP et atténue la fibrose interstitielle rénale et la fibrose hépatique. Le LSKL, inhibiteur de la thrombospondine (TSP-1) TFA supprime la fibrose sous-arachnoÏdienne via l'inhibition de l'activité du TGF-β1 médiée par le TSP-1, prévient le développement de l'hydrocéphalie chronique et améliore les défauts neurocognitifs À long terme après une hémorragie sous-arachnoÏdienne (HSA). Le LSKL, inhibiteur de la thrombospondine (TSP-1) TFA peut facilement traverser la barrière hémato-encéphalique.
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Sample solution is provided at 25 µL, 10mM.
LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a latency-associated protein (LAP)-TGFβ derived tetrapeptide and a competitive TGF-β1 antagonist. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA inhibits the binding of TSP-1 to LAP and alleviates renal interstitial fibrosis and hepatic fibrosis. LSKL, Inhibitor of Thrombospondin (TSP-1) TFA suppresses subarachnoid fibrosis via inhibition of TSP-1-mediated TGF-β1 activity, prevents the development of chronic hydrocephalus and improves long-term neurocognitive defects following subarachnoid hemorrhage (SAH). LSKL, Inhibitor of Thrombospondin (TSP-1) TFA can readily crosse the blood-brain barrier[1][2].
[1]. Liao F, et al. LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1-mediated TGF-β1 signaling activity following subarachnoid hemorrhage in rats. Exp Ther Med. 2016 Oct;12(4):2537-2543. Epub 2016 Aug 31. [2]. Laurent MA, et al. In silico characterization of the interaction between LSKL peptide, a LAP-TGF-beta derived peptide, and ADAMTS1. Comput Biol Chem. 2016 Apr;61:155-61. [3]. Kuroki H, et al. Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor β signal activation and liver regeneration after hepatectomy in an experimental model. Br J Surg. 2015 Jun;102(7):813-25.
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