M 30 dihydrochloride |
| Catalog No.GC50329 |
Le dichlorhydrate de M 30 est un inhibiteur de MAO-A (IC50 = 37 nM) et de MAO-B (IC50 = 57 nM) actif par voie orale, perméable au cerveau et irréversible sélectif pour le cerveau.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 64821-19-8
Sample solution is provided at 25 µL, 10mM.
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Potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson's disease model.
Zheng et al (2005) Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons. Biochem.Pharmacol. 70 1642 PMID:16226724 |Zheng (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition. J.Neurochem. 95 68 PMID:16181413 |Gal et al (2005) Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases. In vivo selective brain monoamine oxidase inhibition and prevention of MPTP-induced striatal DA depletion. J.Neurochem. 95 79 PMID:16181414
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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