MAP4K4-IN-3 |
| Catalog No.GC63059 |
MAP4K4-IN-3 (composé 17) est un inhibiteur puissant et sélectif de MAP4K4 avec une CI50 de 14,9 nM dans le test de kinase, une CI50 de 470 nM dans le test cellulaire.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1811510-58-3
Sample solution is provided at 25 µL, 10mM.
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MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1].
MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic agents[1].
Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) results in a number of adverse effects. Substantial weight losses (7%) and body temperature increases (0.4°C) relative to controls are observed over the course of the study. For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3[2].
[1]. Ammirati M, et al. Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based AntidiabeticTreatment. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.
[2]. Dow RL, et al. 2-Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety. J Med Chem. 2018 Apr 12;61(7):3114-3125.
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