MCC7840 sodium (Synonyms: MCC7840 sodium) |
| Catalog No.GC62454 |
L'emlenoflast (MCC7840) sodium, une sulfonylurée, est un inhibiteur puissant et sélectif de l'inflammasome NLRP3, avec une IC50 <100 nM.
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Cas No.: 2380032-29-9
Sample solution is provided at 25 µL, 10mM.
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MCC7840 sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 sodium can be used for the research of inflammatory diseases[1][2].
MCC7840, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC50 of <100 nM[1].
MCC7840 (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng•h/mL) and CL (0.621 mL/min/kg) in mice[2].MCC7840 (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice[2].
[1]. El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25(23):5533.
[2]. O’neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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