Menin-MLL inhibitor 20 |
| Catalog No.GC63538 |
L'inhibiteur de ménine-MLL 20 est un inhibiteur irréversible de l'interaction ménine-MLL avec des activités antitumorales (WO2020142557A1, intermédiaire 6).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2448173-47-3
Sample solution is provided at 25 µL, 10mM.
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Menin-MLL inhibitor 20 is an irreversible menin-MLL interaction inhibitor with antitumor activities (WO2020142557A1, compound 6)[1].
The Histone-lysine N-methyltransferase 2 (KMT2) family of proteins, which currently consists of at least 5 members, methylate ly sine 4 on the histone H3 tails at important regulatory regions in the genome and thereby impart crucial functions through the modulation of chromatin structures and DNA accessibility. These enzymes are known to play an important role in the regulation of gene expression during early development and hematopoiesis. The human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member in this disease[1].
[1]. Thomas Butler, et al. Irreversible inhibitors of menin-mll interaction. WO2020142557A1.
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