Misoprostol (Synonyms: SC 29333) |
| Catalog No.GC16074 |
Le misoprostol (SC-29333) est un analogue synthétique de la prostaglandine E1 (PGE1) actif par voie orale qui est utilisé pour la recherche sur les ulcères gastriques.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 59122-46-2
Sample solution is provided at 25 µL, 10mM.
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Misoprostol(SC29333) is a synthetic prostaglandin E1 (PGE1) analog that is used to prevent gastric ulcers, to treat missed miscarriage, to induce labor, and to induce abortion.Target: Prostaglandin ReceptorMisoprostol is a synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties. Misoprostol seems to inhibit gastric acid secretion by a direct action on the parietal cells through binding to the prostaglandin receptor. Administration of misoprostol to EP3+/+ and EP3-/- mice showed similar levels of infarct rescue, indicating that misoprostol protection was not mediated through the EP3 receptor. Taken together, these findings suggest a novel function for misoprostol as a protective agent in cerebral ischemia acting via the PGE(2) EP2 and/or EP4 receptors [1, 2].
References:
[1]. Li, J., et al., Misoprostol, an anti-ulcer agent and PGE2 receptor agonist, protects against cerebral ischemia. Neurosci Lett, 2008. 438(2): p. 210-5.
[2]. http://www.drugbank.ca/drugs/DB00929
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