Mivebresib (Synonyms: Mivebresib) |
| Catalog No.GC19248 |
Le mivébrésib (ABBV-075) est un inhibiteur de bromodomaine et de domaine extraterminal (BET) puissant et actif par voie orale. Le mivébrésib se lie À BRD4 avec un Ki de 1,5 nM.
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Cas No.: 1445993-26-9
Sample solution is provided at 25 µL, 10mM.
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Mivebresib is a potent and orally available bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM.
Mivebresib inhibit DHT-stimulated transcription of AR target genes without significant effect on AR protein expression. In addition to blocking the transcription activation downstream of AR, Mivebresib is also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins[1].
References:
[1]. EJ Faivre et al. Abstract 4694: ABBV-075, a novel BET family inhibitor, disrupts critical transcription programs that drive prostate cancer growth to induce potent anti-tumor activity in vitro and in vivo
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