MRT-14 |
Catalog No.GC64419 |
MRT-14 est un puissant antagoniste de Smo. Smo est le composant majeur impliqué dans la transduction du signal des morphogènes Hedgehog (Hh). MRT-14 a le potentiel pour la recherche de plusieurs types de cancers liés À une signalisation Hh anormale.
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Cas No.: 1263131-83-4
Sample solution is provided at 25 µL, 10mM.
MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling[1].
[1]. Manetti F, et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol Pharmacol. 2010;78(4):658-665.
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