N-3-oxo-octanoyl-L-Homoserine lactone (Synonyms: 3-oxo-C8-HSL,N-β-oxo-octanoyl-L-Homoserine lactone，N-(3-Oxooctanoyl)-L-homoserine; N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE) |
Catalog No.GC14832
One-Click Copy Product Info
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N-3-Oxo-octanoyl-L-homoserine lactone est une molécule de signalisation de détection du quorum appartenant à la famille des N-acylhomoserine lactones (AHL), souvent utilisée pour étudier la communication bactérienne et la formation de biofilms.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 147795-39-9
Sample solution is provided at 25 µL, 10mM.
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N-3-Oxo-octanoyl-L-homoserine lactone est une molécule de signalisation de détection du quorum appartenant à la famille des N-acylhomoserine lactones (AHL), souvent utilisée pour étudier la communication bactérienne et la formation de biofilms.[1]. N-3-Oxo-octanoyl-L-homoserine lactone protège Arabidopsis contre un pathogène hémibiotrophe en amorçant la réponse de défense, et cette amorçage médié par N-3-Oxo-octanoyl-L-homoserine lactone nécessite la voie de signalisation de l'acide salicylique (SA)[2]. N-3-Oxo-octanoyl-L-homoserine lactone est largement utilisée pour la protection des plantes et comme référence interne pour le développement de nouvelles méthodes de détection et d'analyse[3].
References:
[1] Aybey A, Sinan S, Askun T. Signal interference effect of human paraoxonase 1 using as substrates N-hexanoyl-L-homoserine lactone and N-3-oxo-octanoyl-L-homoserine lactone on growth of pathogenic bacteria[J]. Applied Biochemistry and Microbiology, 2015, 51(6): 726-731.
[2] Liu F, Zhao Q, Jia Z, et al. N-3-oxo-octanoyl-homoserine lactone-mediated priming of resistance to Pseudomonas syringae requires the salicylic acid signaling pathway in Arabidopsis thaliana[J]. BMC plant biology, 2020, 20(1): 38.
[3] Gosset-Erard C, Han G, Kyrko D, et al. Structural characterization of N-acyl-homoserine lactones from bacterial quorum sensing using LC–MS/MS analyses after Paternò-Büchi derivatization in solution[J]. Analytical and Bioanalytical Chemistry, 2024, 416(25): 5431-5443.
| Cas No. | 147795-39-9 | SDF | |
| Synonymes | 3-oxo-C8-HSL,N-β-oxo-octanoyl-L-Homoserine lactone，N-(3-Oxooctanoyl)-L-homoserine; N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE | ||
| Chemical Name | 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-octanamide | ||
| Canonical SMILES | O=C1[C@@H](NC(CC(CCCCC)=O)=O)CCO1 | ||
| Formula | C12H19NO4 | M.Wt | 241.3 |
| Solubility | 30mg/mL in DMSO, 30mg/mL in DMF, 1mg/mL in Ethanol | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.1442 mL | 20.7211 mL | 41.4422 mL |
| 5 mM | 828.8 μL | 4.1442 mL | 8.2884 mL |
| 10 mM | 414.4 μL | 2.0721 mL | 4.1442 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >97.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)