N-3-oxo-octanoyl-L-Homoserine lactone (Synonyms: 3-oxo-C8-HSL,N-β-oxo-octanoyl-L-Homoserine lactone，N-(3-Oxooctanoyl)-L-homoserine; N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE) |
カタログ番号GC14832
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N-3-Oxo-octanoyl-L-homoserine lactoneはN-アシルホモセリンラクトン(AHL)ファミリーに属するクオラムセンシングシグナル分子であり、細菌のコミュニケーションとバイオフィルムの形成に関する研究によく使われている。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 147795-39-9
Sample solution is provided at 25 µL, 10mM.
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N-3-Oxo-octanoyl-L-homoserine lactoneはN-アシルホモセリンラクトン(AHL)ファミリーに属するクオラムセンシングシグナル分子であり、細菌のコミュニケーションとバイオフィルムの形成に関する研究によく使われている[1]。N-3-Oxo-octanoyl-L-homoserine lactoneは、防御反応をプライミングすることでアラビドプシスを半栄養性病原体から保護し、N-3-Oxo-octanoyl-L-homoserine lactone媒介の準備にSAシグナル経路が必要である[2]。N-3-Oxo-octanoyl-L-homoserine lactoneの事前処理(10μM；2日間)は、病原細菌Pseudomonas syringae pv. tomato DC3000に感染させた後、Arabidopsisは、peroxidase, catalase, phenylalanine ammonialyaseとsuperoxide dismutaseなどの防御関連酵素の活性を増やした[2]。N-3-Oxo-octanoyl-L-homoserine lactoneは、植物保護に広く使われ、新しい検出と分析法の開発に対する内部参照としても使われる[3]。
References:
[1] Aybey A, Sinan S, Askun T. Signal interference effect of human paraoxonase 1 using as substrates N-hexanoyl-L-homoserine lactone and N-3-oxo-octanoyl-L-homoserine lactone on growth of pathogenic bacteria[J]. Applied Biochemistry and Microbiology, 2015, 51(6): 726-731.
[2] Liu F, Zhao Q, Jia Z, et al. N-3-oxo-octanoyl-homoserine lactone-mediated priming of resistance to Pseudomonas syringae requires the salicylic acid signaling pathway in Arabidopsis thaliana[J]. BMC plant biology, 2020, 20(1): 38.
[3] Gosset-Erard C, Han G, Kyrko D, et al. Structural characterization of N-acyl-homoserine lactones from bacterial quorum sensing using LC–MS/MS analyses after Paternò-Büchi derivatization in solution[J]. Analytical and Bioanalytical Chemistry, 2024, 416(25): 5431-5443.
| Cas No. | 147795-39-9 | SDF | |
| 同義語 | 3-oxo-C8-HSL,N-β-oxo-octanoyl-L-Homoserine lactone，N-(3-Oxooctanoyl)-L-homoserine; N-(3-OXOOCTANOYL)-L-HOMOSERINE LACTONE | ||
| Chemical Name | 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-octanamide | ||
| Canonical SMILES | O=C1[C@@H](NC(CC(CCCCC)=O)=O)CCO1 | ||
| Formula | C12H19NO4 | M.Wt | 241.3 |
| 溶解度 | 30mg/mL in DMSO, 30mg/mL in DMF, 1mg/mL in Ethanol | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.1442 mL | 20.7211 mL | 41.4422 mL |
| 5 mM | 828.8 μL | 4.1442 mL | 8.2884 mL |
| 10 mM | 414.4 μL | 2.0721 mL | 4.1442 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >97.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)