N-Arachidonoyl Dopamine (Synonyms: NADA) |
| Catalog No.GC18506 |
La N-Arachidonoyl Dopamine est un agoniste endogène puissant et sélectif des récepteurs CB1 avec un Ki de 250 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 199875-69-9
Sample solution is provided at 25 µL, 10mM.
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Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA), have been isolated and characterized from bovine brain. NADA is the amide of the neurotransmitter dopamine and arachidonic acid. NADA is a CB1-selective agonist, inducing the typical tetrad of hypothermia, analgesia, catalepsy, and hypomotility in rats which exceeds that of anandamide (AEA). NADA is a full agonist at the vanilloid receptor 1, but is inactive on the dopaminergic D1 and D2 receptors. NADA is also a potent inhibitor (IC50 = 0.25 uM) of the proliferation of MCF-7 breast carcinoma cells. Recent reports of NADA’s endothelium-dependent vasodilation indicate that some of its cannabinergic activities antagonized by SR141716A may be non-CB1/CB2 dependent.
Review for N-Arachidonoyl Dopamine
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
Review for N-Arachidonoyl Dopamine
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